ea0006s5 | Newer concepts of mineralocorticoid action | SFE2003
Delcayre C
, Heymes C
, Nehme J
, Ambroisine M
, Robidel E
, De Angelis N
, Milliez P
Aldosterone (Aldo) plays a crucial role in heart remodeling. 1) In presence of high sodium, Aldo induces fibrosis in the cardiovascular system by still partly unknown mechanisms. Aldo-salt induces a pericoronary inflammatory phenotype, that may be one of the first events leading to fibrosis. The RALES trial has evidenced a beneficial effect of spironolactone on both mortality and morbidity in heart failure (HF), that are linked to a reduction of cardiac fibrosis. 2) In rat hea...